This year's Congress focuses on AI and machine learning in medicinal chemistry, exploring how they can improve drug discovery and development and address industry challenges.
Here are some of the ways in which these technologies are transforming the industry:
Improved Target Identification: AI and machine learning algorithms can analyze vast amounts of data to identify new drug targets and predict their function.
Faster Screening of Drug Candidates: CADD tools can be used to screen large libraries of compounds to identify potential drug candidates. This can help to speed up the drug discovery process and reduce the time and cost associated with traditional screening methods.
Rational Drug Design: AI and machine learning algorithms can be used to optimize drug molecules and predict their interactions with specific targets.
Augmented Reality for Drug Design: AR technology can provide an immersive and interactive environment for drug design, allowing researchers to visualize and manipulate molecular structures in 3D.
about Adv. Med Chem 2023 conference
Dear Esteemed Colleagues,
It brings me great pleasure to extend a warm welcome to the “5th Global Summit on Advances in Medicinal Chemistry & Pharmacology,” to be held in the vibrant city of Paris, France from Nov 06-07, 2023.
As always, this year's conference promises to deliver an unparalleled experience of engaging sessions, lectures, and presentations from renowned experts and editors of esteemed journals. With a comprehensive, multidisciplinary program curated by a distinguished international faculty, this year's conference will be focused on the theme of “We’ll look at new technologies and trends in medicinal chemistry and pharmacology that will change the landscape of future drug discovery and development."
Our diverse group of speakers and panelists will provide valuable insights and actionable tools to brainstorm new ideas and discover new skills. With representation from academic institutions, healthcare institutes, pharmaceuticals, biotech, CROs supply chain, logistics, as well as academic scholars and researchers, we are committed to finding more effective ways to evaluate results and impact.
This event provides an exceptional opportunity for professionals to share research and to learn about recent innovations from colleagues around the world.
We are confident that all participants, including students, experts, and policy-makers, will greatly benefit from Adv. Med Chem 2023.
We look forward to a highly informative and stimulating meeting, with critical deliberations and the opportunity to meet new colleagues working in this important field.
With best regards,
Adv. Med Chem 2023
Organizing Committee
Peers Alley Media, Canada
Pontificia Universidad Javeriana, Colombia
Federico II Naples University, Italy
Columbia University, USA
University of Ottawa, Canada
UCL Institute of Neurology, UK
Tong Liao City Hospital, China
Laboratoire D'analyse Des Huile Naturelles, France
Institute of Post Graduate Medical Education and Reseach, India
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Market Value of Medicinal Chemistry in USA
The medicinal chemistry market in the USA is a growing industry that plays a critical role in drug discovery and development. The USA is home to many of the world's leading pharmaceutical companies and research institutions, which are driving innovation and pushing the boundaries of drug discovery and development.
According to a report by Grand View Research, the global medicinal chemistry market was valued at USD 281.9 billion in 2020 and is expected to grow at a CAGR of 5.6% from 2021 to 2028. This growth is driven by the increasing prevalence of chronic diseases, the growing demand for personalized medicine, and the increasing adoption of advanced technologies such as AI and genomics in drug discovery and development.
In the USA, the market is dominated by large pharmaceutical companies such as Pfizer, Merck, and Johnson & Johnson, which invest heavily in research and development to bring new drugs to market. The industry is also supported by a vibrant ecosystem of small and mid-sized biotech companies, as well as academic research institutions, that are driving innovation in the field.
The COVID-19 pandemic has also had a significant impact on the medicinal chemistry market in the USA, with many companies shifting their focus to developing treatments and vaccines for the virus. The pandemic has also highlighted the importance of drug discovery and development, and has accelerated the adoption of new technologies and approaches in the field.
Overall, the medicinal chemistry market in the USA is expected to continue to grow in the coming years, driven by advances in technology, increasing demand for personalized medicine, and the growing prevalence of chronic diseases.
Market Value of Medicinal Chemistry in Europe
Medicinal chemistry is a field that combines knowledge of chemistry, biochemistry, and pharmacology to design and develop new drugs for the treatment of diseases. It is a critical component of the pharmaceutical industry and has a significant impact on the healthcare sector.
The European pharmaceutical industry is one of the largest in the world, with many major pharmaceutical companies headquartered in Europe. According to a report by the European Federation of Pharmaceutical Industries and Associations (EFPIA), the pharmaceutical industry in Europe spent over €35 billion on research and development in 2020.
The market value of medicinal chemistry in Europe is influenced by various factors, including the demand for new drugs, the cost of research and development, regulatory requirements, and competition from generic drugs. The market is also impacted by trends in healthcare, such as the increasing prevalence of chronic diseases and the growing focus on personalized medicine.
Overall, the market value of medicinal chemistry in Europe is significant, and the field is likely to continue to play a critical role in the healthcare sector in the coming years.
Market Value of Medicinal Chemistry in Asia
The medicinal chemistry market in Asia is growing rapidly and is expected to continue to do so in the coming years. Asia is home to some of the largest pharmaceutical markets in the world, such as China, Japan, and India. The increasing demand for drugs to treat various diseases, including cancer, diabetes, and cardiovascular diseases, is driving the growth of the medicinal chemistry market in Asia.
According to a report by Mordor Intelligence, the Asian medicinal chemistry market was valued at USD 34.05 billion in 2020 and is expected to reach USD 58.58 billion by 2026, growing at a CAGR of 9.23% during the forecast period (2021-2026).
Factors contributing to the growth of the medicinal chemistry market in Asia include the increasing investment in research and development, the availability of a skilled workforce, and the growing demand for affordable and effective drugs. The increasing adoption of advanced technologies such as artificial intelligence and machine learning in drug discovery is also expected to boost the market's growth.
In summary, the medicinal chemistry market in Asia is growing rapidly and is expected to continue to do so in the coming years, driven by factors such as increasing demand for drugs, investment in research and development, and adoption of advanced technologies.
Global Market Value of Pharmaceutical Chemistry:
The pharmaceutical chemistry market is an essential component of the pharmaceutical industry, which involves the discovery, development, and manufacturing of drugs for the treatment of diseases. The market is driven by several factors, including the increasing prevalence of chronic diseases, the aging population, and the rising demand for personalized medicine.
According to a report by Zion Market Research, the global pharmaceutical chemistry market was valued at USD 44.5 billion in 2020 and is expected to reach USD 61.2 billion by 2028, growing at a CAGR of 4.1% during the forecast period (2021-2028).
The pharmaceutical chemistry market is segmented into various categories, including API synthesis, drug formulation, analytical services, and others. The API synthesis segment dominates the market, accounting for the largest share due to the increasing demand for active pharmaceutical ingredients (APIs) in drug development.
The market is also driven by increasing investment in research and development, the adoption of advanced technologies, and the growing demand for generic drugs. The pharmaceutical industry is heavily regulated, and various government bodies and organizations set the standards for drug development and manufacturing, which also influences the market's growth.
In summary, the global pharmaceutical chemistry market is growing and is expected to continue to do so in the coming years, driven by various factors such as increasing demand for APIs, investment in research and development, adoption of advanced technologies, and government regulations.
List of Medicinal Chemistry Companies:
Pfizer Inc. | AstraZeneca | Merck & Co., Inc. | Novartis AG | GlaxoSmithKline (GSK) | Johnson & Johnson | Eli Lilly and Company | Bristol-Myers Squibb | Sanofi S.A. | AbbVie Inc. | Roche Holding AG | Boehringer Ingelheim | Takeda Pharmaceutical Company Limited | Bayer AG | Astellas Pharma Inc. | Daiichi Sankyo Company Limited | Amgen Inc. | Vertex Pharmaceuticals Incorporated | Eisai Co., Ltd. | Biogen Inc. | Gilead Sciences, Inc. | Kyowa Kirin Co., Ltd. | Sumitomo Dainippon Pharma Co., Ltd. | Teva Pharmaceutical Industries Ltd. | Otsuka Pharmaceutical Co., Ltd. | Lundbeck A/S | H. Lundbeck A/S | Mallinckrodt Pharmaceuticals | Endo Pharmaceuticals Inc. | Mallinckrodt plc | Jazz Pharmaceuticals | Kyorin Pharmaceutical Co., Ltd. | The Medicines Company | Zhejiang Hisun Pharmaceutical Co., Ltd. | Alkermes plc | Sun Pharmaceutical Industries Ltd. | Taro Pharmaceutical Industries Ltd. | Zydus Cadila | Aspen Pharmacare Holdings Limited | Lupin Limited | Jubilant Life Sciences Limited | Cipla Limited | Dr. Reddy's Laboratories Ltd. | Torrent Pharmaceuticals Ltd. | Alembic Pharmaceuticals Limited | Hikal Limited | Cambrex Corporation | ChemDiv, Inc. | Hetero Drugs Limited | Torrent Pharma Inc. | Eurofins Scientific SE | Piramal Pharma Solutions | Wuxi AppTec Co., Ltd. | Jubilant Chemsys Limited | WuXi STA | Syngene International Limited | GVK BIO | Evotec SE | Charles River Laboratories International, Inc. | Lonza Group AG | Samsung BioLogics | Catalent, Inc. | Siegfried Holding AG | Cambrex Corporation | Patheon N.V. | AMRI | Fujifilm Diosynth Biotechnologies | Almac Group | Recipharm AB | Sandoz International GmbH | Laurus Labs Limited | Glenmark Pharmaceuticals Limited | Cadila Healthcare Limited | LEO Pharma A/S | Alembic Pharmaceuticals Limited | Macleods Pharmaceuticals Limited | Rusan Pharma Limited | Granules India Limited | Ind-Swift Laboratories Ltd. | Neuland Laboratories Limited | Dishman Carbogen Amcis Limited | SRS Pharmaceuticals Pvt. Ltd. | ZCL Chemicals Ltd. | USV Private Limited | Samarth Life Sciences Pvt. Ltd. | Chiral Technologies, Inc. | Chemo S.A. | Vifor Pharma Group | Alphapharm Pty Ltd | Glenmark Generics Ltd. | Biocad | Nanjing Chuanbai Pharmaceutical Co., Ltd. | Eisai Co., Ltd. | Chugai Pharmaceutical Co., Ltd. | Otsuka Pharmaceutical Co.,
List of Medicinal Chemistry Universities:
University of California, San Francisco (UCSF), USA | University of Cambridge, UK | Harvard University, USA | University of Oxford, UK | ETH Zurich, Switzerland | University of Tokyo, Japan | Massachusetts Institute of Technology (MIT), USA | University of Toronto, Canada | University of California, San Diego (UCSD), USA | Imperial College London, UK | University of Michigan, USA | Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland | University of Illinois at Urbana-Champaign, USA | National University of Singapore (NUS), Singapore | University of Basel, Switzerland | University of Chicago, USA | University of California, Los Angeles (UCLA), USA | University of Pennsylvania, USA | Kyoto University, Japan | University of California, Berkeley, USA | Peking University, China | University of Texas at Austin, USA | University of California, Irvine (UCI), USA | Columbia University, USA | University of Copenhagen, Denmark | University of Wisconsin-Madison, USA | University of Manchester, UK | University of Sydney, Australia | University of California, Davis (UCD), USA | Johns Hopkins University, USA | University of Edinburgh, UK | University of Zurich, Switzerland | University of Hong Kong (HKU), Hong Kong | University of Minnesota, USA | National Taiwan University (NTU), Taiwan | University of British Columbia, Canada | University of Melbourne, Australia | Duke University, USA | University of Amsterdam, Netherlands | University of North Carolina at Chapel Hill, USA | University of Nottingham, UK | University of Heidelberg, Germany | Australian National University (ANU), Australia | Tsinghua University, China | University of Bristol, UK | University of California, Riverside (UCR), USA | University of Leeds, UK | University of Queensland, Australia | University of Alberta, Canada | University of Sheffield, UK | University of Western Australia, Australia | University of Iowa, USA | University of Glasgow, UK | University of California, Santa Cruz (UCSC), USA | University of Southampton, UK | University of Georgia, USA | University of Southern California (USC), USA | University of Vienna, Austria | University of Utah, USA | University of Warwick, UK | University of Arizona, USA | University of Paris-Sud, France | University of Virginia, USA | University of Helsinki, Finland | University of California, Santa Barbara (UCSB), USA | University of Geneva, Switzerland | University of California, Merced (UCM), USA | University of Hamburg, Germany | University of Kentucky, USA | University of Freiburg, Germany | University of Maryland, USA | University of Erlangen-Nuremberg, Germany | University of Illinois at Chicago (UIC), USA | University of Auckland, New Zealand | University of Arizona, USA | University of Oregon, USA | University of Alberta, Canada | University of Western Ontario, Canada | University of Colorado Boulder, USA | University of Bergen, Norway
List of Medicinal Chemistry Associations:
American Chemical Society, Division of Medicinal Chemistry | European Federation of Medicinal Chemistry | International Society of Heterocyclic Chemistry | International Society for the Study of Xenobiotics | American Association of Pharmaceutical Scientists | American Society of Pharmacognosy | Society for Medicinal Plant and Natural Product Research | International Society for the History of Pharmacy | International Association for Pharmaceutical Technology | International Society for Antiviral Research | International Society of Chemical Biology | International Society for Molecular Recognition | International Society for Neurochemistry | International Society for the Study of Pain | International Society for Vaccines | International Union of Basic and Clinical Pharmacology | Society of Toxicology | American Society for Mass Spectrometry | American Society for Pharmacology and Experimental Therapeutics | Royal Society of Chemistry, Biological and Medicinal Chemistry Sector | European Association of Nuclear Medicine | European Federation for Pharmaceutical Sciences | European Peptide Society | Federation of Asian Chemical Societies | International Association of Therapeutic Drug | Monitoring and Clinical Toxicology | International Chemical Biology Society | International Chemical Congress of Pacific Basin Societies | International Medicinal Chemistry Symposium | International Symposium on Reactive Intermediates and Unusual Molecules | International Society of Chemotherapy for Infection and Cancer | International Society of Nucleosides, Nucleotides and Nucleic Acids | American Society for Clinical Pharmacology and Therapeutics | Society for Laboratory Automation and Screening | Society for Medicinal Chemistry and Chemical Biology of Eastern Africa | Society of Nuclear Medicine and Molecular Imaging | European Crystallographic Association | Federation of Analytical Chemistry and Spectroscopy Societies | International Association of Pharmaceutical Scientists and Engineers | International Chemical Congress of Pacific Basin Societies | International Isotope Society | International Society for Extracellular Vesicles | International Society for the Advancement of Supercritical Fluids | International Society for the Study of Xenobiotics | Medicinal Chemistry Section of the Société Chimique de France | National Association of Industrial and Technical Chemistry | Society for Applied Spectroscopy | Society for Biological Engineering | Society for Biomaterials | Society for Chemical Hazard Communication | Society for Chemical Industry | Society for Medicinal Chemistry of Canada | Society for Pharmaceutical Dissolution Science | Society for Pharmaceutical Engineering | Society for the Study of Inborn Errors of Metabolism | Society of Chemical Manufacturers and Affiliates | Society of Cosmetic Chemists | Society of Environmental Toxicology and Chemistry | Society of Forensic Toxicologists | Society of Toxicologic Pathology | American Society for Biochemistry and Molecular Biology | American Society for Clinical Laboratory Science | American Society for Microbiology | American Society of Gene and Cell Therapy | Association of Biomolecular Resource Facilities | Association of Clinical Research Professionals | Biophysical Society | Chemical Abstracts Service | Chemical Society of Japan | Drug Information Association | European Society for Clinical Investigation | European Society for Evolutionary Biology | European Society for Gene and Cell Therapy | European Society for Paediatric Infectious Diseases | European Society for Photobiology | European Society for Virology | Federation of European Biochemical Societies
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Rare earth elements (REEs) are indispensable components in a number of technological devices, with steadily growing literature since the 1950s. The published data highlight both favorable and adverse effects, as far as REEs, like other xenobiotics, follow hormetic concentration-related trends, implying stimulatory or protective effects at low levels, then adverse effects at higher concentrations. Thus, it is important to investigate REEs in different matrices to evaluate the risks or benefits of these emergent contaminants. REE mixtures have been used in Chinese agriculture as fertilizers for more than 30 years to improve crop yields. Furthermore, REE supplementation positively affects both animal growth and feed conversion efficiency (FCE) in pigs, broilers and cattle, and egg production in laying hens. More recently, the use of REE-based fertilizers and feed additives has been prospected to a number of other countries outside China. Our on-going study of REE-associated hormetic effects relies on a recent investigation on sub-micromolar cerium (Ce), lanthanum (La) and their equimolar concentrations on sperm fertilization success and offspring quality of Sphaerechinus granularis sea urchins, with the prospected effects of sperm of Paracentrotus lividus sea urchins. The current results assessed an increase in sperm fertilization success and an improvement of offspring quality following sperm exposure to sub-micromolar concentrations of Ce, La, or their combination. Previous data showed different toxicities in a set of REE analogues, thus a working hypothesis is raised about extending this comparative dataset among several REEs in terms of hormetic effects.
Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at suboptimal targets. To achieve progress, consideration needs to be given to the role of cell aging in disease pathogenesis. We propose a model unifying the fundamental processes underlying most age-associated cardiovascular pathologies. According to this model, cell aging, leading to cell senescence, is responsible for tissue changes leading to age-related cardiovascular disease. This process, occurring due to telomerase inactivation and telomere attrition, affects all components of the cardiovascular system, including cardiomyocytes, vascular endothelial cells, smooth muscle cells, cardiac fibroblasts, and immune cells. The unified model offers insights into the relationship between upstream risk factors and downstream clinical outcomes and explains why interventions aimed at either of these components have limited success. Potential therapeutic approaches are considered based on this model. Because telomerase activity can prevent and reverse cell senescence, telomerase gene therapy is discussed as a promising intervention. Telomerase gene therapy and similar systems interventions based on the unified model are expected to be transformational in cardiovascular medicine.
Despite many advantages offered by titanium alloys compared to other conventional materials in the industry, several manufacturing challenges arise, and they are associated with titanium’s mechanical, thermal, and chemical properties. As a result of these characteristics, titanium alloys are low-machinability materials. Machining path strategies have proven their influence over surface finishing, machining forces, and tool life to reduce machinability-related problems. Most studies have shown the impact of the path strategies on frontal or end milling processes, and few are related to side (tangential) milling. Finally, based on the self-propelled rotary tool (SPRT) technique, which alters the cutting tool portion during machining, this work evaluates surface finishing behavior, machining forces, and tool life using two different tool path strategies (sinusoidal and linear) on the side milling of Ti-6Al-4 V alloy. The results show that the association between an adequate tool path strategy (sinusoidal) and the cutting parameters improves surface finishing (more than 130%), decreases cutting forces (about 20%), changes tool wear mechanisms, and increases tool life significantly (4–5 times) without productivity loss. Wear mechanisms that promote notch wear were suppressed, and uniform flank wear predominated. Consequently, the sinusoidal path has brought benefits to the cutting process. It is a technology that can have great interest and is easily applicable in the industry.