Dear Esteemed Colleagues,
We are delighted to extend a heartfelt welcome to the forthcoming "6th Global Summit on Advances in Medicinal Chemistry & Pharmacology," scheduled to take place in the dynamic city of Amsterdam, Netherlands on April 03-04, 2025.
This year's conference assures an exceptional experience featuring engaging sessions, lectures, and presentations by distinguished experts and editors of esteemed journals. Featuring an extensive and diverse agenda meticulously crafted by a renowned international faculty, this year's conference will center around the compelling theme, "Innovations Shaping the Future: Transformative Technologies in Medicinal Chemistry & Pharmacology."
Our array of speakers and panelists, representing diverse sectors such as academic institutions, healthcare institutes, pharmaceuticals, biotech, CROs, supply chain, logistics, and academic scholars, is poised to deliver valuable insights and actionable tools to brainstorm new ideas and discover new skills.
This event serves as an outstanding platform for professionals to exchange research findings and stay abreast of recent innovations from colleagues worldwide. We have full confidence that all attendees, encompassing students, experts, and policy-makers, will derive substantial benefits from their participation in Adv. Med Chem 2025.
We look forward to a highly informative and stimulating meeting, with critical deliberations and the opportunity to meet new colleagues working in this important field.
With best regards,
Adv. Med Chem 2025
Organizing Committee
Peers Alley Media, Canada
Harvard Medical School, USA
Cleveland Diagnostics, USA
Antares Health Products Inc., East Tennessee State University, USA
University of Illinois, USA
Maxillo Facial Surgery Unit, Italy
Laboratoire D'analyse Des Huile Naturelles, France
Telocyte, Grand Rapids, USA
Almendra Americas, USA
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Market Value of Medicinal Chemistry in USA
The medicinal chemistry market in the USA is a growing industry that plays a critical role in drug discovery and development. The USA is home to many of the world's leading pharmaceutical companies and research institutions, which are driving innovation and pushing the boundaries of drug discovery and development.
According to a report by Grand View Research, the global medicinal chemistry market was valued at USD 281.9 billion in 2020 and is expected to grow at a CAGR of 5.6% from 2021 to 2028. This growth is driven by the increasing prevalence of chronic diseases, the growing demand for personalized medicine, and the increasing adoption of advanced technologies such as AI and genomics in drug discovery and development.
In the USA, the market is dominated by large pharmaceutical companies such as Pfizer, Merck, and Johnson & Johnson, which invest heavily in research and development to bring new drugs to market. The industry is also supported by a vibrant ecosystem of small and mid-sized biotech companies, as well as academic research institutions, that are driving innovation in the field.
The COVID-19 pandemic has also had a significant impact on the medicinal chemistry market in the USA, with many companies shifting their focus to developing treatments and vaccines for the virus. The pandemic has also highlighted the importance of drug discovery and development, and has accelerated the adoption of new technologies and approaches in the field.
Overall, the medicinal chemistry market in the USA is expected to continue to grow in the coming years, driven by advances in technology, increasing demand for personalized medicine, and the growing prevalence of chronic diseases.
Market Value of Medicinal Chemistry in Europe
Medicinal chemistry is a field that combines knowledge of chemistry, biochemistry, and pharmacology to design and develop new drugs for the treatment of diseases. It is a critical component of the pharmaceutical industry and has a significant impact on the healthcare sector.
The European pharmaceutical industry is one of the largest in the world, with many major pharmaceutical companies headquartered in Europe. According to a report by the European Federation of Pharmaceutical Industries and Associations (EFPIA), the pharmaceutical industry in Europe spent over €35 billion on research and development in 2020.
The market value of medicinal chemistry in Europe is influenced by various factors, including the demand for new drugs, the cost of research and development, regulatory requirements, and competition from generic drugs. The market is also impacted by trends in healthcare, such as the increasing prevalence of chronic diseases and the growing focus on personalized medicine.
Overall, the market value of medicinal chemistry in Europe is significant, and the field is likely to continue to play a critical role in the healthcare sector in the coming years.
Market Value of Medicinal Chemistry in Asia
The medicinal chemistry market in Asia is growing rapidly and is expected to continue to do so in the coming years. Asia is home to some of the largest pharmaceutical markets in the world, such as China, Japan, and India. The increasing demand for drugs to treat various diseases, including cancer, diabetes, and cardiovascular diseases, is driving the growth of the medicinal chemistry market in Asia.
According to a report by Mordor Intelligence, the Asian medicinal chemistry market was valued at USD 34.05 billion in 2020 and is expected to reach USD 58.58 billion by 2026, growing at a CAGR of 9.23% during the forecast period (2021-2026).
Factors contributing to the growth of the medicinal chemistry market in Asia include the increasing investment in research and development, the availability of a skilled workforce, and the growing demand for affordable and effective drugs. The increasing adoption of advanced technologies such as artificial intelligence and machine learning in drug discovery is also expected to boost the market's growth.
In summary, the medicinal chemistry market in Asia is growing rapidly and is expected to continue to do so in the coming years, driven by factors such as increasing demand for drugs, investment in research and development, and adoption of advanced technologies.
Global Market Value of Pharmaceutical Chemistry:
The pharmaceutical chemistry market is an essential component of the pharmaceutical industry, which involves the discovery, development, and manufacturing of drugs for the treatment of diseases. The market is driven by several factors, including the increasing prevalence of chronic diseases, the aging population, and the rising demand for personalized medicine.
According to a report by Zion Market Research, the global pharmaceutical chemistry market was valued at USD 44.5 billion in 2020 and is expected to reach USD 61.2 billion by 2028, growing at a CAGR of 4.1% during the forecast period (2021-2028).
The pharmaceutical chemistry market is segmented into various categories, including API synthesis, drug formulation, analytical services, and others. The API synthesis segment dominates the market, accounting for the largest share due to the increasing demand for active pharmaceutical ingredients (APIs) in drug development.
The market is also driven by increasing investment in research and development, the adoption of advanced technologies, and the growing demand for generic drugs. The pharmaceutical industry is heavily regulated, and various government bodies and organizations set the standards for drug development and manufacturing, which also influences the market's growth.
In summary, the global pharmaceutical chemistry market is growing and is expected to continue to do so in the coming years, driven by various factors such as increasing demand for APIs, investment in research and development, adoption of advanced technologies, and government regulations.
List of Medicinal Chemistry Companies:
Pfizer Inc. | AstraZeneca | Merck & Co., Inc. | Novartis AG | GlaxoSmithKline (GSK) | Johnson & Johnson | Eli Lilly and Company | Bristol-Myers Squibb | Sanofi S.A. | AbbVie Inc. | Roche Holding AG | Boehringer Ingelheim | Takeda Pharmaceutical Company Limited | Bayer AG | Astellas Pharma Inc. | Daiichi Sankyo Company Limited | Amgen Inc. | Vertex Pharmaceuticals Incorporated | Eisai Co., Ltd. | Biogen Inc. | Gilead Sciences, Inc. | Kyowa Kirin Co., Ltd. | Sumitomo Dainippon Pharma Co., Ltd. | Teva Pharmaceutical Industries Ltd. | Otsuka Pharmaceutical Co., Ltd. | Lundbeck A/S | H. Lundbeck A/S | Mallinckrodt Pharmaceuticals | Endo Pharmaceuticals Inc. | Mallinckrodt plc | Jazz Pharmaceuticals | Kyorin Pharmaceutical Co., Ltd. | The Medicines Company | Zhejiang Hisun Pharmaceutical Co., Ltd. | Alkermes plc | Sun Pharmaceutical Industries Ltd. | Taro Pharmaceutical Industries Ltd. | Zydus Cadila | Aspen Pharmacare Holdings Limited | Lupin Limited | Jubilant Life Sciences Limited | Cipla Limited | Dr. Reddy's Laboratories Ltd. | Torrent Pharmaceuticals Ltd. | Alembic Pharmaceuticals Limited | Hikal Limited | Cambrex Corporation | ChemDiv, Inc. | Hetero Drugs Limited | Torrent Pharma Inc. | Eurofins Scientific SE | Piramal Pharma Solutions | Wuxi AppTec Co., Ltd. | Jubilant Chemsys Limited | WuXi STA | Syngene International Limited | GVK BIO | Evotec SE | Charles River Laboratories International, Inc. | Lonza Group AG | Samsung BioLogics | Catalent, Inc. | Siegfried Holding AG | Cambrex Corporation | Patheon N.V. | AMRI | Fujifilm Diosynth Biotechnologies | Almac Group | Recipharm AB | Sandoz International GmbH | Laurus Labs Limited | Glenmark Pharmaceuticals Limited | Cadila Healthcare Limited | LEO Pharma A/S | Alembic Pharmaceuticals Limited | Macleods Pharmaceuticals Limited | Rusan Pharma Limited | Granules India Limited | Ind-Swift Laboratories Ltd. | Neuland Laboratories Limited | Dishman Carbogen Amcis Limited | SRS Pharmaceuticals Pvt. Ltd. | ZCL Chemicals Ltd. | USV Private Limited | Samarth Life Sciences Pvt. Ltd. | Chiral Technologies, Inc. | Chemo S.A. | Vifor Pharma Group | Alphapharm Pty Ltd | Glenmark Generics Ltd. | Biocad | Nanjing Chuanbai Pharmaceutical Co., Ltd. | Eisai Co., Ltd. | Chugai Pharmaceutical Co., Ltd. | Otsuka Pharmaceutical Co.,
List of Medicinal Chemistry Universities:
University of California, San Francisco (UCSF), USA | University of Cambridge, UK | Harvard University, USA | University of Oxford, UK | ETH Zurich, Switzerland | University of Tokyo, Japan | Massachusetts Institute of Technology (MIT), USA | University of Toronto, Canada | University of California, San Diego (UCSD), USA | Imperial College London, UK | University of Michigan, USA | Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland | University of Illinois at Urbana-Champaign, USA | National University of Singapore (NUS), Singapore | University of Basel, Switzerland | University of Chicago, USA | University of California, Los Angeles (UCLA), USA | University of Pennsylvania, USA | Kyoto University, Japan | University of California, Berkeley, USA | Peking University, China | University of Texas at Austin, USA | University of California, Irvine (UCI), USA | Columbia University, USA | University of Copenhagen, Denmark | University of Wisconsin-Madison, USA | University of Manchester, UK | University of Sydney, Australia | University of California, Davis (UCD), USA | Johns Hopkins University, USA | University of Edinburgh, UK | University of Zurich, Switzerland | University of Hong Kong (HKU), Hong Kong | University of Minnesota, USA | National Taiwan University (NTU), Taiwan | University of British Columbia, Canada | University of Melbourne, Australia | Duke University, USA | University of Amsterdam, Netherlands | University of North Carolina at Chapel Hill, USA | University of Nottingham, UK | University of Heidelberg, Germany | Australian National University (ANU), Australia | Tsinghua University, China | University of Bristol, UK | University of California, Riverside (UCR), USA | University of Leeds, UK | University of Queensland, Australia | University of Alberta, Canada | University of Sheffield, UK | University of Western Australia, Australia | University of Iowa, USA | University of Glasgow, UK | University of California, Santa Cruz (UCSC), USA | University of Southampton, UK | University of Georgia, USA | University of Southern California (USC), USA | University of Vienna, Austria | University of Utah, USA | University of Warwick, UK | University of Arizona, USA | University of Paris-Sud, France | University of Virginia, USA | University of Helsinki, Finland | University of California, Santa Barbara (UCSB), USA | University of Geneva, Switzerland | University of California, Merced (UCM), USA | University of Hamburg, Germany | University of Kentucky, USA | University of Freiburg, Germany | University of Maryland, USA | University of Erlangen-Nuremberg, Germany | University of Illinois at Chicago (UIC), USA | University of Auckland, New Zealand | University of Arizona, USA | University of Oregon, USA | University of Alberta, Canada | University of Western Ontario, Canada | University of Colorado Boulder, USA | University of Bergen, Norway
List of Medicinal Chemistry Associations:
American Chemical Society, Division of Medicinal Chemistry | European Federation of Medicinal Chemistry | International Society of Heterocyclic Chemistry | International Society for the Study of Xenobiotics | American Association of Pharmaceutical Scientists | American Society of Pharmacognosy | Society for Medicinal Plant and Natural Product Research | International Society for the History of Pharmacy | International Association for Pharmaceutical Technology | International Society for Antiviral Research | International Society of Chemical Biology | International Society for Molecular Recognition | International Society for Neurochemistry | International Society for the Study of Pain | International Society for Vaccines | International Union of Basic and Clinical Pharmacology | Society of Toxicology | American Society for Mass Spectrometry | American Society for Pharmacology and Experimental Therapeutics | Royal Society of Chemistry, Biological and Medicinal Chemistry Sector | European Association of Nuclear Medicine | European Federation for Pharmaceutical Sciences | European Peptide Society | Federation of Asian Chemical Societies | International Association of Therapeutic Drug | Monitoring and Clinical Toxicology | International Chemical Biology Society | International Chemical Congress of Pacific Basin Societies | International Medicinal Chemistry Symposium | International Symposium on Reactive Intermediates and Unusual Molecules | International Society of Chemotherapy for Infection and Cancer | International Society of Nucleosides, Nucleotides and Nucleic Acids | American Society for Clinical Pharmacology and Therapeutics | Society for Laboratory Automation and Screening | Society for Medicinal Chemistry and Chemical Biology of Eastern Africa | Society of Nuclear Medicine and Molecular Imaging | European Crystallographic Association | Federation of Analytical Chemistry and Spectroscopy Societies | International Association of Pharmaceutical Scientists and Engineers | International Chemical Congress of Pacific Basin Societies | International Isotope Society | International Society for Extracellular Vesicles | International Society for the Advancement of Supercritical Fluids | International Society for the Study of Xenobiotics | Medicinal Chemistry Section of the Société Chimique de France | National Association of Industrial and Technical Chemistry | Society for Applied Spectroscopy | Society for Biological Engineering | Society for Biomaterials | Society for Chemical Hazard Communication | Society for Chemical Industry | Society for Medicinal Chemistry of Canada | Society for Pharmaceutical Dissolution Science | Society for Pharmaceutical Engineering | Society for the Study of Inborn Errors of Metabolism | Society of Chemical Manufacturers and Affiliates | Society of Cosmetic Chemists | Society of Environmental Toxicology and Chemistry | Society of Forensic Toxicologists | Society of Toxicologic Pathology | American Society for Biochemistry and Molecular Biology | American Society for Clinical Laboratory Science | American Society for Microbiology | American Society of Gene and Cell Therapy | Association of Biomolecular Resource Facilities | Association of Clinical Research Professionals | Biophysical Society | Chemical Abstracts Service | Chemical Society of Japan | Drug Information Association | European Society for Clinical Investigation | European Society for Evolutionary Biology | European Society for Gene and Cell Therapy | European Society for Paediatric Infectious Diseases | European Society for Photobiology | European Society for Virology | Federation of European Biochemical Societies
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While pregnant women often self-medicate with acetaminophen (paracetamol/APAP) or NSAIDs such as ibuprofen (IBU), infants are commonly treated with these drugs for their analgesic and antipyretic effects. Epidemiological studies have found association between maternal use of APAP and NSAIDs and the incidence of reproductive disorders in male babies. Using rodent models, we previously found that neonatal gonocytes, as well as juvenile spermatogonia and Sertoli cells express cyclooxygenase (Cox) 1 and 2 and other eicosanoid pathway enzymes, and produce prostaglandin (PG) E2, D2 and F2a (1-4). Thus, we tested the hypothesis that exposing infants to APAP or IBU could disrupt the development and function of their testes, potentially affecting their future reproductive health, using in vivo and in vitro rodent models. Mouse spermatogonial and Sertoli cell lines, as well as corresponding cells from rat pups were treated with APAP, IBU and selective Cox inhibitors, revealing differentially expressed genes, functional pathways and proteins following treatments. Data with Cox1-depleted spermatogonia and pharmacological inhibitors suggested opposite roles for Cox1 and 2 on spermatogonial differentiation, with Cox1 preventing differentiation and Cox2 promoting it (5). In vivo treatments of neonatal rats from postnatal day (PND) 1 to PND4 or 7 with APAP and IBU, at doses previously reported in children’s blood, unveiled morphological and protein pattern alterations in testes, some persisting until adulthood, and changes in adult testosterone levels. Moreover, single cell-RNA-seq analysis of PND8 testes uncovered common and unique differentially altered genes in key testicular cell types between APAP and IBU. These findings indicate that exposing rat pups and testicular cells to APAP and IBU can disrupt testicular function in short- and long-term manner, further suggesting using caution when treating infants with these drugs.
(E)-(R)-4-Thujanol present in thyme essential oil, is a flavoring agent with a menthol flavor. As (E)-(R)-4-thujanol is always a minor component in the natural extracts, the large scale productions of the pure compound is not economically viable. I report here an eco- responsible method to produce (E)-(R)-4-thujanol crystals on a kilogram scale. This new process involves (i) the use of a selected wild thyme (Thymus vulgaris) and (ii) a water steam distillation, producing an organic aromatic oil with high content of (E)-(R)-4-thujanol. Interestingly due to a favorable amphipathic partition at the air-water interface, (E)-(R)-4- thujanol forms spontaneously a crude crystal. Gas chromatography revealed a composition made of (E)-(R)-4-thujanol (60-75%) and others minors monoterpenes. The crude crystal submitted to several cycles of vaporization/crystallization, led to accumulate translucent fibers made of (E)-(R)-4-thujanol (up to 99%). X-ray diffraction unambiguously demonstrated that crystals of (E)-(R)-4-thujanol forms a trimer unit. The trimers superpose themselves to construct a chiral P-type supramolecular helix. Deep inside the helix, each alcoholic function is engaged in two hydrogen bonds, thus forming a continuous backbone (see illustration). Crystals are very stable at room temperature, and can be melted and reconstructed several times. Some pharmaceutical applications may benefit from this, as compared to the polymorphous and unstable menthol crystal.
Rare earth elements (REEs) are indispensable components in a number of technological devices, with steadily growing literature since the 1950s. The published data highlight both favorable and adverse effects, as far as REEs, like other xenobiotics, follow hormetic concentration-related trends, implying stimulatory or protective effects at low levels, then adverse effects at higher concentrations. Thus, it is important to investigate REEs in different matrices to evaluate the risks or benefits of these emergent contaminants. REE mixtures have been used in Chinese agriculture as fertilizers for more than 30 years to improve crop yields. Furthermore, REE supplementation positively affects both animal growth and feed conversion efficiency (FCE) in pigs, broilers and cattle, and egg production in laying hens. More recently, the use of REE-based fertilizers and feed additives has been prospected to a number of other countries outside China. Our on-going study of REE-associated hormetic effects relies on a recent investigation on sub-micromolar cerium (Ce), lanthanum (La) and their equimolar concentrations on sperm fertilization success and offspring quality of Sphaerechinus granularis sea urchins, with the prospected effects of sperm of Paracentrotus lividus sea urchins. The current results assessed an increase in sperm fertilization success and an improvement of offspring quality following sperm exposure to sub-micromolar concentrations of Ce, La, or their combination. Previous data showed different toxicities in a set of REE analogues, thus a working hypothesis is raised about extending this comparative dataset among several REEs in terms of hormetic effects.